Platelet coagulation factor Va: the major secretory platelet phosphoprotein
نویسندگان
چکیده
منابع مشابه
Platelet coagulation factor Va: the major secretory platelet phosphoprotein.
Platelet-derived coagulation factor Va is the primary secreted substrate for a thrombin-stimulation-dependent platelet kinase. Human platelet factor Va, consisting of a molecular weight (M(r)) 105,000 heavy chain and an M(r) 74,000 light chain, incorporates phosphate in at least two sites on the light chain. Phosphorylated factor Va represents 50% of the secreted protein-associated phosphate. T...
متن کاملPlatelet and Coagulation
HIV-1 seropositive individuals: homosexuals (1), intravenous narcotic addicts (2), hemophiliacs (3), and their heterosexual partners (4) develop chronic immunologic thrombocytopenic purpura (ITP). The thrombocytopenia can present early in the course of HIV-1-infection as well as in association with AIDS. The early onset disease (emphasized in this review) is clinically indistinguishable from cl...
متن کاملFlow Cytometric Measurement of CD41/CD61, CD42b Platelet Receptors and Platelet Factor 3 Activity in Lyophilized Infusible Platelet Membrane Preparation
Background: The short life time of human platelet units has led to a chronic shortage of fresh platelets in blood transfusion centers. Many approaches have been investigated experimentally to produce new hemostatically active platelet products that are capable of long term storage. Infusible platelet membrane (IPM) prepared from fresh or outdated human platelets have been developed as an altern...
متن کاملActivation of coagulation factor V by a platelet protease.
Factor V must be converted to Factor V(a) in order to bind to a high affinity platelet surface site and participate in prothrombin activation. Osterud et al. (10) presented data that suggested that human platelets contain an activated form of Factor V and a Factor V activator. We find that the Factor V released when platelets are disrupted by freezing and thawing or sonication is activated 3- t...
متن کاملPlatelet heterogeneity: variation in coagulation complexes on platelet subpopulations.
OBJECTIVE Previous work has shown that platelets stimulated with the combination of thrombin and convulxin, a glycoprotein VI agonist, develop 2 populations with different levels of alpha-granule factor V bound to the platelet surface. To evaluate whether this phenomenon is restricted to alpha-granule components or is a feature that can be generalized to other coagulation factors, we studied th...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Blood
سال: 1994
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v83.8.2180.2180